Nucleoplasmic and cytoplasmic glycoproteins.

  title={Nucleoplasmic and cytoplasmic glycoproteins.},
  author={Gerald W. Hart and Robert S. Haltiwanger and G. D. Holt and William G. Kelly},
  journal={Ciba Foundation symposium},
  pages={102-12, discussion 112-8}
We have described a new form of protein glycosylation in which N-acetylglucosamine is glycosidically linked to the hydroxyl of serine or threonine (O-GlcNAc). Unlike most other forms of protein glycosylation, O-GlcNAc is predominantly localized in the nuclear and cytoplasmic compartments of cells, where it occurs on important nuclear pore glycoproteins, well-characterized cytoskeletal proteins, as well as on many chromatin proteins, including factors that regulate gene transcription. Gas-phase… CONTINUE READING