Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.

@article{Maggi2008NucleophosminSA,
  title={Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.},
  author={Leonard Maggi and Michael Kuchenruether and David Y. A. Dadey and Rachel M Schwope and Silvia Grisendi and R. Reid Townsend and Pier Paolo Pandolfi and Jason D. Weber},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 23},
  pages={7050-65}
}
Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified mechanism for NPM's role in cell growth; NPM directs the nuclear export of both 40S and 60S ribosomal subunits. NPM interacts with rRNA and large and small ribosomal subunit proteins and also colocalizes with large and small ribosomal subunit proteins in the nucleolus, nucleus, and cytoplasm. The… CONTINUE READING

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