Nucleophosmin is selectively deposited on mRNA during polyadenylation

  title={Nucleophosmin is selectively deposited on mRNA during polyadenylation},
  author={Viswanathan Palaniswamy and Karen C.M. Moraes and Carol J Wilusz and Jeffrey Wilusz},
  journal={Nature Structural &Molecular Biology},
Nucleophosmin (NPM), an abundant, predominantly nucleolar protein that influences numerous cellular processes, was shown to specifically associate with the bodies of messenger RNAs as a result of the process of 3′-end formation. NPM deposition requires polyadenylation but not the 3′ cleavage event to occur on the transcript. Furthermore, the protein does… CONTINUE READING