Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction.

@article{Inder2009NucleophosminAN,
  title={Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction.},
  author={Kerry L. Inder and Chiyan Lau and Dorothy Loo and Natasha Chaudhary and Andrew Goodall and Sally Martin and Alun Jones and Dharini van der Hoeven and Robert G. Parton and Michelle M. Hill and John F Hancock},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 41},
  pages={28410-9}
}
The spatial organization of Ras proteins into nanoclusters on the inner leaflet of the plasma membrane is essential for high fidelity signaling through the MAPK pathway. Here we identify two selective regulators of K-Ras nanoclustering from a proteomic screen for K-Ras interacting proteins. Nucleophosmin (NPM) and nucleolin are predominantly localized to the nucleolus but also have extranuclear functions. We show that a subset of NPM and nucleolin localizes to the inner leaflet of plasma… CONTINUE READING