Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases

@article{Colombo2011NucleophosminAI,
  title={Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases},
  author={Emanuela Colombo and Myriam Alcalay and Pier Giuseppe Pelicci},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={2595-2609}
}
Nucleophosmin (NPM, also known as B23, numatrin or NO38) is a ubiquitously expressed phosphoprotein belonging to the nucleoplasmin family of chaperones. NPM is mainly localized in the nucleolus where it exerts many of its functions, but a proportion of the protein continuously shuttles between the nucleus and the cytoplasm. A growing number of cellular proteins have been described as physical interactors of NPM, and consequently, NPM is thought to have a relevant role in diverse cellular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 2016
View 11 Excerpts
Highly Influenced

Targeting the nucleolus for cancer intervention.

Biochimica et biophysica acta • 2014
View 11 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 175 references

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function.

Molecular and cellular biology • 2005
View 6 Excerpts
Highly Influenced

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…