Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

@article{Liu2012NucleophosminI,
  title={Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.},
  author={Xijun Liu and Dan Liu and Dongmeng Qian and Jenny Dai and Yi An and Shaoyan Jiang and Bruce A. Stanley and Jin-ming Yang and Bin Wang and Xin-Yuan Liu and David Xianhong Liu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 23},
  pages={19599-609}
}
Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation. NPM1 is expressed weakly in hepatocytes and highly expressed in hepatocellular carcinomas (HCC) with a clear correlation between enhanced NPM1 expression and increased tumor grading and poor prognosis, whereas in contrast, ATF5 is expressed abundantly in hepatocytes and down-regulated in HCC. Re-expression of ATF5 in HCC inhibits cell proliferation. We report… CONTINUE READING