Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

  title={Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication},
  author={Masaru Okuda and Henning F. Horn and Pheruza Tarapore and Yukari Tokuyama and A.George Smulian and P. K. Chan and Erik S. Knudsen and Irene A Hofmann and Jean D. Snyder and Kevin E. Bove and Kenji Fukasawa},
In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E in centrosome duplication. NPM/B23 associates specifically with unduplicated centrosomes, and NPM/B23 dissociates from centrosomes by CDK2/cyclin E-mediated phosphorylation. An anti-NPM/B23 antibody, which blocks this phosphorylation… CONTINUE READING
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Cyclin - dependent Zeiss 912 transmission electron microscope . kinase control of centrosome duplication

  • B. M. H. Lange, K. Gull
  • Proc . Natl . Acad . Sci . USA
  • 1999

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