Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

  title={Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins},
  author={Vladimir L. Rusinov and Irina M Sapozhnikova and E. N. Ulomskii and N. R. Medvedeva and Vladimir V. Egorov and Oleg I. Kiselev and E. G. Deeva and Andrey V. Vasin and Oleg N. Chupakhin},
  journal={Chemistry of Heterocyclic Compounds},
The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives. 

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