Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.

Abstract

[reaction: see text] Activation of substituted 1,1-diarylmethanols as their corresponding toluenesulfonates and subsequent displacement with a range of carbon, nitrogen, oxygen, and sulfur nucleophiles proceeds in 81-96% yield. Enantiomerically enriched diarylmethanols 8a-c were activated and displaced with pyridine acetate enolate with complete… (More)

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@article{Bolshan2004NucleophilicDA, title={Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.}, author={Yuri Bolshan and Cheng-Yi Chen and Jennifer R Chilenski and Francis Gosselin and David J. Mathre and Paul D. O'Shea and Am{\'e}lie Roy and Richard D. Tillyer}, journal={Organic letters}, year={2004}, volume={6 1}, pages={111-4} }