Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry.

Abstract

Dynamic covalent chemistry uses reversible chemical reactions to set up an equilibrating network of molecules at thermodynamic equilibrium, which can adjust its composition in response to any agent capable of altering the free energy of the system. When the target is a biological macromolecule, such as a protein, the process corresponds to the protein… (More)
DOI: 10.1038/nchem.658

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