Nucleolin stimulates viral internal ribosome entry site-mediated translation.

  title={Nucleolin stimulates viral internal ribosome entry site-mediated translation.},
  author={Raquel E Izumi and Benjam{\'i}n Valdez and Rajeev Banerjee and Monika Srivastava and Asim K. Dasgupta},
  journal={Virus research},
  volume={76 1},
Previous results from our laboratory have identified a small (60 nt) RNA from the yeast S. cerevisiae that specifically inhibits internal ribosome entry site (IRES)-mediated translation programmed by poliovirus (PV) and hepatitis C virus (HCV) 5'-untranslated region (5'UTR). The yeast inhibitor RNA (called IRNA) was found to efficiently compete with viral 5'UTR for binding of several cellular polypeptides that presumably play important roles in IRES-mediated translation. One such IRNA (and 5… CONTINUE READING


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