Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.


Recruitment of DNA repair factors and modulation of chromatin structure at sites of DNA double-strand breaks (DSBs) is a complex and highly orchestrated process. We developed a system that can induce DSBs rapidly at defined endogenous sites in mammalian genomes and enables direct assessment of repair and monitoring of protein recruitment, egress, and… (More)
DOI: 10.1073/pnas.1306160110


6 Figures and Tables