Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin.

@article{Shi2007NucleolinIA,
  title={Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin.},
  author={Hubing Shi and Yujie Huang and H. Zhou and X. Song and S. Yuan and Y. Fu and Y. Luo},
  journal={Blood},
  year={2007},
  volume={110 8},
  pages={
          2899-906
        }
}
The exact molecular mechanism of how endostatin inhibits angiogenesis and tumor growth remains uncharacterized. Here, we report that endostatin specifically binds to the cell surface nucleolin with high affinity. Blockage of nucleolin by a neutralizing antibody or knockdown of nucleolin by the RNA interference results in loss of antiendothelial activities of endostatin. Importantly, a neutralizing antinucleolin antibody abrogates the antiangiogenic and antitumor activities of endostatin in vivo… Expand
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