Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression

@inproceedings{Miniard2010NucleolinBT,
  title={Nucleolin binds to a subset of selenoprotein mRNAs and regulates their
expression},
  author={Angela C. Miniard and Lisa M. Middleton and Michael E. Budiman and Carri A. Gerber and Donna M. Driscoll},
  booktitle={Nucleic acids research},
  year={2010}
}
Selenium, an essential trace element, is incorporated into selenoproteins as selenocysteine (Sec), the 21st amino acid. In order to synthesize selenoproteins, a translational reprogramming event must occur since Sec is encoded by the UGA stop codon. In mammals, the recoding of UGA as Sec depends on the selenocysteine insertion sequence (SECIS) element, a stem-loop structure in the 3' untranslated region of the transcript. The SECIS acts as a platform for RNA-binding proteins, which mediate or… CONTINUE READING

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