Nucleolar size indicates the rapidity of cell proliferation in cancer tissues.

@article{Derenzini2000NucleolarSI,
  title={Nucleolar size indicates the rapidity of cell proliferation in cancer tissues.},
  author={Massimo Derenzini and Davide Trer{\'e} and Annalisa Pession and Maurizio Govoni and Valentina Sirri and Pasquale Chieco},
  journal={The Journal of pathology},
  year={2000},
  volume={191 2},
  pages={181-6}
}
In order to define the importance of the nucleolus in tumour pathology, the relationship between nucleolar size and function and tumour mass growth rate was studied in vivo. Ten established human cancer cell lines from colon carcinomas and neuroblastomas were inoculated subcutaneously in athymic mice and the doubling time (DT) of the xenograft tumour mass was calculated. The tumour DTs ranged from 3.2 to 15.7 days. Nucleolar size was evaluated in sections from formalin-fixed and paraffin… CONTINUE READING

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Neither the MIB1 , PCNA or BrdU LIs were related to the xenograft tumour mass DT , showing that the different growth rates of tumour xenografts were not due to different growth fractions , but were mainly related to different cell proliferation rates .
Neither the MIB1 , PCNA or BrdU LIs were related to the xenograft tumour mass DT , showing that the different growth rates of tumour xenografts were not due to different growth fractions , but were mainly related to different cell proliferation rates .
Neither the MIB1 , PCNA or BrdU LIs were related to the xenograft tumour mass DT , showing that the different growth rates of tumour xenografts were not due to different growth fractions , but were mainly related to different cell proliferation rates .
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