• DOI:10.1038/nature03207
Corpus ID: 4344740

Nucleolar proteome dynamics

@article{Andersen2005NucleolarPD,
  title={Nucleolar proteome dynamics},
  author={J. Andersen and Y. Lam and A. Leung and S. Ong and C. Lyon and A. Lamond and M. Mann},
  journal={Nature},
  year={2005},
  volume={433},
  pages={77-83}
}

• J. Andersen, Y. Lam, +4 authors M. Mann
• Published 2005
• Biology, Medicine
• Nature

The nucleolus is a key organelle that coordinates the synthesis and assembly of ribosomal subunits and forms in the nucleus around the repeated ribosomal gene clusters. Because the production of ribosomes is a major metabolic activity, the function of the nucleolus is tightly linked to cell growth and proliferation, and recent data suggest that the nucleolus also plays an important role in cell-cycle regulation, senescence and stress responses. Here, using mass-spectrometry-based organellar… Expand

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