Nucleolar proteome dynamics

  title={Nucleolar proteome dynamics},
  author={J. Andersen and Y. Lam and Anthony K. L. Leung and S. Ong and C. Lyon and A. Lamond and M. Mann},
  • J. Andersen, Y. Lam, +4 authors M. Mann
  • Published 2005
  • Biology, Medicine
  • Nature
  • The nucleolus is a key organelle that coordinates the synthesis and assembly of ribosomal subunits and forms in the nucleus around the repeated ribosomal gene clusters. Because the production of ribosomes is a major metabolic activity, the function of the nucleolus is tightly linked to cell growth and proliferation, and recent data suggest that the nucleolus also plays an important role in cell-cycle regulation, senescence and stress responses. Here, using mass-spectrometry-based organellar… CONTINUE READING
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