Nucleolar localization signals of box H/ACA small nucleolar RNAs.

  title={Nucleolar localization signals of box H/ACA small nucleolar RNAs.},
  author={Aarthi Narayanan and Anna Lukowiak and Be{\'a}ta E. J{\'a}dy and François Dragon and Tam{\'a}s Kiss and Rebecca M. Terns and Michael P Terns},
  journal={The EMBO journal},
  volume={18 18},
The two major families of small nucleolar RNAs (snoRNAs), Box C/D and Box H/ACA, are generated in the nucleoplasm and transported to the nucleolus where they function in rRNA processing and modification. We have investigated the sequences involved in the intranuclear transport of Box H/ACA snoRNAs by assaying the localization of injected fluorescent RNAs in Xenopus oocyte nuclear spreads. Our analysis of U17, U64 and U65 has revealed that disruption of either of the conserved sequence elements… CONTINUE READING
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