Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.

@article{Rieker2011NucleolarDI,
  title={Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.},
  author={Claus Rieker and David Engblom and Grzegorz Kreiner and Andrii Domanskyi and Andreas Schober and Stefanie Stotz and Manuela Neumann and Xuejun Yuan and Ingrid Grummt and G. Sch{\"u}tz and Rosanna Parlato},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 2},
  pages={
          453-60
        }
}
The nucleolus represents an essential stress sensor for the cell. However, the molecular consequences of nucleolar damage and their possible link with neurodegenerative diseases remain to be elucidated. Here, we show that nucleolar damage is present in both genders in Parkinson's disease (PD) and in the pharmacological PD model induced by the neurotoxin 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine hydrochloride (MPTP). Mouse mutants with nucleolar disruption restricted to dopaminergic (DA… CONTINUE READING
Highly Cited
This paper has 46 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

mTOR in Brain Physiology and Pathologies.

Physiological reviews • 2015
View 6 Excerpts
Highly Influenced

How Parkinson's disease meets nucleolar stress.

Biochimica et biophysica acta • 2014
View 8 Excerpts
Highly Influenced