Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

  title={Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan},
  author={Tobias Eisenberg and Sabrina Schroeder and Aleksandra S. Andryushkova and Tobias Pendl and Victoria K{\"u}ttner and Anuradha Bhukel and Guillermo Marin͂o and Federico Pietrocola and Alexandra Harger and Andreas S. Zimmermann and Tarek Moustafa and Adrian Sprenger and Evelyne Jany and Sabrina Buettner and Didac Carmona-Guti{\'e}rrez and Christoph Ruckenstuhl and Julia Ring and Wieland Reichelt and Katharina Schimmel and Tina Leeb and Claudia Moser and Stefanie Schatz and L P Kamolz and Christoph Magnes and Frank Sinner and Simon Sedej and K U Fr{\"o}hlich and G{\'a}bor Juh{\'a}sz and Thomas R. Pieber and J{\"o}rn Dengjel and Stephan J. Sigrist and Guido Kroemer and Frank Madeo},
  booktitle={Cell metabolism},
Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast. Blocking the mitochondrial route to AcCoA by deletion of the CoA-transferase ACH1 caused cytosolic accumulation of the AcCoA precursor acetate. This led… CONTINUE READING
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