Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.

  title={Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.},
  author={Anton Chestukhin and Larisa Litovchick and Katherine Rudich and James A. DeCaprio},
  journal={Molecular and cellular biology},
  volume={22 2},
The retinoblastoma-related pocket proteins pRb, p107, and p130 are implicated in the control of cell proliferation, differentiation, and transformation. The function of pocket proteins is in part mediated by their ability to inhibit specific E2F transcription factors. The transcriptional activity of E2Fs is controlled by alteration of their nucleocytoplasmic localization during the cell cycle. p130 was observed to shuttle between the nucleus and cytoplasm in a heterokaryon fusion assay… CONTINUE READING


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