Nucleocytoplasmic shuttling and the control of NF-AT signaling

@article{Zhu2000NucleocytoplasmicSA,
  title={Nucleocytoplasmic shuttling and the control of NF-AT signaling},
  author={Jiangyu Zhu and Frank McKeon},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2000},
  volume={57},
  pages={411-420}
}
The nuclear factors of activated T cells (NF-ATs) constitute a family of transcription factors that transduce calcium signals in the immune, cardiac, muscular and nervous systems. Like their distant relatives of the Rel family, including NF-κB, NF-ATs are cytoplasmic in resting cells and activated by means of induced nuclear import. Unlike NF-κB, however, NF-ATs show highly dynamic nuclear shuttling properties that have important implications for graded signaling by these molecules. This review… CONTINUE READING
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