Nucleocytoplasmic shuttling and the control of NF-AT signaling

  title={Nucleocytoplasmic shuttling and the control of NF-AT signaling},
  author={Jiangyu Zhu and Frank McKeon},
  journal={Cellular and Molecular Life Sciences CMLS},
The nuclear factors of activated T cells (NF-ATs) constitute a family of transcription factors that transduce calcium signals in the immune, cardiac, muscular and nervous systems. Like their distant relatives of the Rel family, including NF-κB, NF-ATs are cytoplasmic in resting cells and activated by means of induced nuclear import. Unlike NF-κB, however, NF-ATs show highly dynamic nuclear shuttling properties that have important implications for graded signaling by these molecules. This review… CONTINUE READING
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Regulation of the calmodulin - stimulated protein phosphatase , calcineurin

  • B. KleeC., H. Ren, X. Wang
  • J . Biol . Chem .
  • 1998

Role of the NF - ATc transcription factor in morphogenesis of cardiac valves and septum [ see comments ]

  • L. delaPompaJ., A. TimmermanL., H. Takimoto, H. Yoshida, J. EliaA., E. Samper
  • Nature
  • 1998

The transcription factor NF - ATc is essential for cardiac valve formation [ see comments ]

  • M. RangerA., J. GrusbyM., R. HodgeM., M. GravalleseE., C. delaBrousseF., T. Hoey
  • Nature
  • 1998

The transcription factor NFAT 4 is involved in the generation and survival of T cells

  • M. Oukka, C. HoI., C. delaBrousseF., T. Hoey, J. GrusbyM., H. GlimcherL.
  • Immunity
  • 1998

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