Nucleocytoplasmic protein transport and recycling of Ran.

  title={Nucleocytoplasmic protein transport and recycling of Ran.},
  author={Yoshihiro Yoneda and Miki Hieda and Emi Nagoshi and Yoichi Miyamoto},
  journal={Cell structure and function},
  volume={24 6},
The active transport of proteins into and out of the nucleus is mediated by specific signals, the nuclear localization signal (NLS) and nuclear export signal (NES), respectively. The best characterized NLS is that of the SV40 large T antigen, which contains a cluster of basic amino acids. The NESs were first identified in the protein kinase inhibitor (PKI) and HIV Rev protein, which are rich in leucine residues. The SV40 T-NLS containing transport substrates are carried into the nucleus by an… CONTINUE READING


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