Corpus ID: 15726961

Nucleocytoplasmic Translocation of UBXN 2 A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells

  title={Nucleocytoplasmic Translocation of UBXN 2 A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells},
  author={A. Abdullah and S. Sane and Jessica L. Freeling and Hongmin Wang and Dong Zhang and K. Rezvani},
The subcellular localization, expression level, and activity of anti-cancer proteins alter in response to intrinsic and extrinsic cellular stresses to reverse tumor progression. The purpose of this study is to determine whether UBXN2A, an activator of the p53 tumor suppressor protein, has different subcellular compartmentalization in response to the stress of DNA damage. We measured trafficking of the UBXN2A protein in response to two different DNA damage stresses, UVB irradiation and the… Expand

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