Nucleocapsid- and virus-like particles assemble in cells infected with recombinant baculoviruses or vaccinia viruses expressing the M and the S segments of Hantaan virus.

@article{Betenbaugh1995NucleocapsidAV,
  title={Nucleocapsid- and virus-like particles assemble in cells infected with recombinant baculoviruses or vaccinia viruses expressing the M and the S segments of Hantaan virus.},
  author={Michael J. Betenbaugh and Min Yu and Kathleen Kuehl and Jamie White and David G Pennock and Kristin W. Spik and Connie S. Schmaljohn},
  journal={Virus research},
  year={1995},
  volume={38 2-3},
  pages={111-24}
}
The formation of Hantaan (HTN) virus nucleocapsid-like structures (NLS) or virus-like particles (VLP) from expressed gene products was investigated in two eukaryotic systems. Baculovirus expression of the HTN virus small segment (S), which encodes the viral nucleocapsid protein, resulted in assembly of NLS inside infected insect cells. The NLS and authentic ribonucleocapsids, prepared by detergent disruption of HTN virions, had similar sedimentation characteristics and morphologies, and were… CONTINUE READING
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