Nucleocapsid and glycoprotein organization in an enveloped virus

  title={Nucleocapsid and glycoprotein organization in an enveloped virus},
  author={Russell C. H. Cheng and Richard J. Kuhn and Norman H. Olson and Michael G RossmannHok-Kin Choi and Thomas James Smith and Timothy S. Baker},
Alphaviruses are a group of icosahedral, positive-strand RNA, enveloped viruses. The membrane bilayer, which surrounds the approximately 400 A diameter nucleocapsid, is penetrated by 80 spikes arranged in a T = 4 lattice. Each spike is a trimer of heterodimers consisting of glycoproteins E1 and E2. Cryoelectron microscopy and image reconstruction of Ross River virus showed that the T = 4 quaternary structure of the nucleocapsid consists of pentamer and hexamer clusters of the capsid protein… CONTINUE READING
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