Nucleobase-containing metallated polymeric resins as artificial phosphodiesterases: kinetics of hydrolysis, pH dependence, and catalyst recycling.

@article{Srivatsan2001NucleobasecontainingMP,
  title={Nucleobase-containing metallated polymeric resins as artificial phosphodiesterases: kinetics of hydrolysis, pH dependence, and catalyst recycling.},
  author={Seergazhi G Srivatsan and Sandeep Verma},
  journal={Chemistry},
  year={2001},
  volume={7 4},
  pages={828-33}
}
Two metallated polymeric resins that contain the nucleobase adenine have been investigated for their ability to catalyze the hydrolysis of model phosphodiester substrates. These resins behave in a catalytic manner and display classical Michaelis-Menten kinetics. Consequently, parameters such as kobs, Km, Vmax, and kcat were determined for the two resins for… CONTINUE READING