Nucleo-Cytoplasmic Localization Domains Regulate Krüppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function

  title={Nucleo-Cytoplasmic Localization Domains Regulate Kr{\"u}ppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function},
  author={Estefan{\'i}a Rodr{\'i}guez and Nana Aburjania and Nolan Michael Priedigkeit and Analisa Difeo and John A. Martignetti},
  booktitle={PloS one},
BACKGROUND The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene. As a consequence of splicing, KLF6-SV1 loses both the C-terminus C2H2 three zinc finger (ZF) domain, which characterizes all KLF proteins, as well as the adjacent 5' basic region (5BR), a putative nuclear localization signal (NLS). It has been hypothesized that this NLS is a functional… CONTINUE READING
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