Nucleic acids in prion preparations: unspecific background or essential component?

@article{Kellings1994NucleicAI,
  title={Nucleic acids in prion preparations: unspecific background or essential component?},
  author={Klaus Kellings and Stanley B Prusiner and Detlev Riesner},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1994},
  volume={343 1306},
  pages={425-30}
}
As recently published (Kellings et al. J. gen Vir. 73, 1025-1029 (1992)), the analysis of purified scrapie prions by return refocusing gel electrophoresis revealed remaining nucleic acids in the size range up to 1100 nucleotides. The results defined the possible characteristics of a hypothetical scrapie-specific nucleic acid. If homogeneous in size, such a molecule would be less than 80 nucleotides in length at a particle-to-infectivity ratio (P:I) near unity; if heterogeneous, scrapie-specific… CONTINUE READING