Nucleic acid-binding polymers as anti-inflammatory agents.

@article{Lee2011NucleicAP,
  title={Nucleic acid-binding polymers as anti-inflammatory agents.},
  author={Jaewoo Lee and Jang Wook Sohn and Ying Zhang and Kam W Leong and David S. Pisetsky and Bruce A. Sullenger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={14055-60}
}
Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundancy of the TLR family encouraged us to seek materials that can neutralize the proinflammatory effects of any nucleic acid regardless of its sequence, structure or chemistry. Herein… CONTINUE READING
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