Nucleic acid aptamers for targeting of shRNA-based cancer therapeutics

  title={Nucleic acid aptamers for targeting of shRNA-based cancer therapeutics},
  author={John S. Vorhies and John Nemunaitis},
  booktitle={Biologics : targets & therapy},
Aptamers are nucleic acid ligands which have been validated to bind to epitopes with a specificity similar to that of monoclonal antibodies. Aptamers have been primarily investigated for their direct function in terms of inhibition of protein targets; however, recent evidence gives reason to actively explore aptamers as targeting moieties for delivery of anticancer therapeutics. Many aptamers have been developed to bind to extracellular membrane domains of proteins overexpressed on cancer cells… CONTINUE READING
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