• Corpus ID: 16641896

Nucleic Acid Enzymes: The Fusion of Self-assembly and Conformational Computing

@article{Ramlan2009NucleicAE,
  title={Nucleic Acid Enzymes: The Fusion of Self-assembly and Conformational Computing},
  author={Effirul Ikhwan Ramlan and Klaus-Peter Zauner},
  journal={Int. J. Unconv. Comput.},
  year={2009},
  volume={5},
  pages={165-189}
}
Macromolecules are the predominant physical substrate sup-porting information processing in organisms. Two key characteristics—conformational dynamics and self-assembly properties—render macro-molecules unique in this context. Both characteristics have been investigated for technical applications. In nature’s information processors self-assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best… 
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4 Citations
Background Citations
2
Methods Citations
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Results Citations
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4 Citations

Citation Type

Citation Type

Functional nucleic acids as substrate for information processing
TLDR
This thesis investigated, to what extent the construction of molecular building blocks for a particular purpose is possible with the support of a software environment, and developed a computational protocol that functions on a multi-molecular level, which enable it to directly incorporate the dynamic characteristics of nucleic acids molecules.
In-silico design of computational nucleic acids for molecular information processing
TLDR
This study demonstrates the simplicity with which one can construct a set of nucleic acid computing units using a new computational protocol that would enable the construction of a network of interconnecting nucleic acids (as a circuit) for molecular information processing.
Design of interacting multi-stable nucleic acids for molecular information processing
AN EXTENDED DOT-BRACKET-NOTATION FOR FUNCTIONAL NUCLEIC ACIDS
TLDR
An extension for the syntax of the standard dot-bracket notation is proposed to increase its convenience and expressive power for both its use to communicate nucleic acid secondary structures among humans and machines and for functional nucleic acids in general.

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