Nuclei and subnuclei gene expression profiling in mammalian brain.

  title={Nuclei and subnuclei gene expression profiling in mammalian brain.},
  author={Pascal Bonaventure and Hongqing Guo and Bin Tian and Xuejun Liu and Anton Bittner and Barbara Roland and Ranelle C Salunga and X Ma and Fredrik Kamme and Bernhard H. Meurers and Margot H M Bakker and Mirek Jurzak and Jos{\'e}e E. Leysen and Mark G. Erlander},
  journal={Brain research},
  volume={943 1},
Information on the neuroanatomical expression of a given gene is critical to understanding its function in the central nervous system. The integration of laser capture microdissection (LCM), T7-based RNA amplification and cDNA microarrays allows for this information to be simultaneously generated for thousands of genes. To validate this integrative approach, we catalogued the gene expression profiles of seven rat brain nuclei or subnuclei. A hundred cells from the following seven brain nuclei… CONTINUE READING