Nucleation free energy of pore formation in an amphiphilic bilayer studied by molecular dynamics simulations.

Abstract

The formation of a pore in a membrane requires a considerable rearrangement of the amphiphilic molecules about to form the bilayer edge surrounding the pore, and hence is accompanied by a steep increase of the free energy. Recent rupture and conductance experiments suggest that this reshuffling process is also responsible for a small energy barrier that… (More)

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@article{Tolpekina2004NucleationFE, title={Nucleation free energy of pore formation in an amphiphilic bilayer studied by molecular dynamics simulations.}, author={Tanya V. Tolpekina and Willem den Otter and W. J. Briels}, journal={The Journal of chemical physics}, year={2004}, volume={121 23}, pages={12060-6} }