Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins.

@article{Hunter1996NucleationAI,
  title={Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins.},
  author={Graeme K. Hunter and Peter V. Hauschka and A. Robin Poole and Lawrence C. Rosenberg and Harvey A. Goldberg},
  journal={The Biochemical journal},
  year={1996},
  volume={317 ( Pt 1)},
  pages={59-64}
}
Many proteins found in mineralized tissues have been proposed to function as regulators of the mineralization process, either as nucleators or inhibitors of hydroxyapatite (HA) formation. We have studied the HA-nucleating and HA-inhibiting properties of proteins from bone [osteocalcin (OC), osteopontin (OPN), osteonectin (ON) and bone sialoprotein (BSP)], dentine [phosphophoryn (DPP)] and calcified cartilage [chondrocalcin (CC)] over a wide range of concentrations. Nucleation of HA was studied… CONTINUE READING

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