Nucleation and crystal growth in supersaturated solutions of a model drug.

@article{Lindfors2008NucleationAC,
  title={Nucleation and crystal growth in supersaturated solutions of a model drug.},
  author={Lennart Lindfors and Sara Forss{\'e}n and Jan Westergren and Ulf Olsson},
  journal={Journal of colloid and interface science},
  year={2008},
  volume={325 2},
  pages={404-13}
}
The crystallization process in aqueous solutions of the drug bicalutamide and the effect of the polymer polyvinylpyrrolidone (PVP) have been studied. Results showed that PVP decreased the crystallization rate significantly in a system with PVP concentrations as low as 0.01% (w/w), without changing the polymorph formed. The crystal habit was altered already at PVP concentrations as low as 0.001% (w/w). Measurements made with self-diffusion NMR indicated that the decrease in crystallization rate… CONTINUE READING

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