Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.

@article{Flory1996NucleaseresistantRD,
  title={Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.},
  author={Craig M. Flory and Pamela A. Pavco and Thale C. Jarvis and Mark E. Lesch and Francine E. Wincott and Leonid Beigelman and Stephen W. Hunt and Denis J. Schrier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 2},
  pages={754-8}
}
Catalytic RNA molecules, or ribozymes, have generated significant interest as potential therapeutic agents for controlling gene expression. Although ribozymes have been shown to work in vitro and in cellular assays, there are no reports that demonstrate the efficacy of synthetic, stabilized ribozymes delivered in vivo. We are currently utilizing the rabbit model of interleukin 1-induced arthritis to assess the localization, stability, and efficacy of exogenous antistromelysin hammerhead… CONTINUE READING

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