Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer

@article{Srinivasan2011NuclearVD,
  title={Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer},
  author={Malini Srinivasan and Anil V. Parwani and Pamela A. Hershberger and Diana E. Lenzner and Joel L. Weissfeld},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2011},
  volume={123},
  pages={30-36}
}
Vitamin D has been shown to have anti-proliferative effects in a wide variety of cancers including lung cancer. The anticancer effects of vitamin D are mediated primarily by its active metabolite, 1,25-dihydroxyvitamin D (calcitriol), through vitamin D receptor (VDR) signaling. However, thus far there have been no studies evaluating the association between VDR expression and survival outcome in lung cancer. Using immunohistochemical analysis, we evaluated VDR expression, separately in the… CONTINUE READING

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