Nuclear transport of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in opossum kidney cells.

@article{Li1997NuclearTO,
  title={Nuclear transport of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in opossum kidney cells.},
  author={Wu Li and Janet Fawcett and Hans Ruedi Widmer and Paul J. Fielder and Ralph Rabkin and Gilbert A. Keller},
  journal={Endocrinology},
  year={1997},
  volume={138 4},
  pages={1763-6}
}
When added to cultured opossum kidney cells, IGF-I is internalized and transported to distinct intracellular compartments that depend on the cell location within the monolayer. In resting cells away from the periphery of the monolayer, IGF-I is internalized by a clathrin coated pit pathway and delivered to the endosomal compartment. In contrast, cells growing at the edges of a monolayer or an experimental wound internalize IGF-I by an alternative route which rapidly delivers IGF-I to the… CONTINUE READING

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