Nuclear transport and transcription.

  title={Nuclear transport and transcription.},
  author={Arash Komeili and Erin K O'Shea},
  journal={Current opinion in cell biology},
  volume={12 3},
The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport plays a crucial role in regulating the activity of many transcription factors. 

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