Nuclear transplantation: lessons from frogs and mice.

  title={Nuclear transplantation: lessons from frogs and mice.},
  author={Konrad Hochedlinger and Rudolf Jaenisch},
  journal={Current opinion in cell biology},
  volume={14 6},
Nuclear transplantation was developed 50 years ago in frogs to test whether nuclei from differentiated cells remain genetically equivalent to zygotic nuclei. Results from cloning experiments in frogs and mice indicate that nuclei gradually lose potency during development from embryonic to adult cells. However, even though adult mature lymphocytes were recently shown to remain genetically totipotent, no evidence exists to show that surviving clones originate from the nuclei of terminally… CONTINUE READING

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