Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects.

@article{Podlecki1987NuclearTO,
  title={Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects.},
  author={D A Podlecki and Ryan M. Smith and Ming-Ching Kao and Phoebe Tsai and Thomas P. Huecksteadt and Dietrich Brandenburg and Robert S. Lasher and Laura R. Jarett and Jerrold M. Olefsky},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 7},
  pages={
          3362-8
        }
}
The translocation of occupied surface insulin receptors to the nuclei of isolated hepatocytes was studied using the biologically active photosensitive insulin derivative, B2(2-nitro-4-azidophenylacetyl)-des-PheB1-insulin (NAPA-DP-insulin). When hepatocytes were photolabeled at 4 degrees C, extensively washed, and then further incubated at 37 degrees C for 1 h, photolabeled insulin receptors, which were initially localized to the cell surface, accumulated in the subsequently isolated nuclei… CONTINUE READING
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