Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.

@article{Wang2009NuclearTO,
  title={Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.},
  author={Shao-chun Wang and M -C Hung},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 21},
  pages={6484-9}
}
Integral membrane proteins contain a hydrophobic transmembrane domain and mainly locate in the plasma membrane lipid bilayer. The receptor tyrosine kinases (RTK) of the epidermal growth factor receptor (EGFR) superfamily, including ErbB-1, ErbB-2, ErbB-3, and ErbB-4, constitute an important group of such membrane proteins, which have a profound impact on cancer initiation, progression, and patient outcome. Although studies of their functions have conventionally focused on their membrane… CONTINUE READING
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