Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.

@article{Tabuchi2005NuclearTO,
  title={Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.},
  author={Akiko Tabuchi and Marcel Estevez and Jennifer Agraz Henderson and Ruth Marx and Jun Shiota and Hiroyasu Nakano and Jay M Baraban},
  journal={Journal of neurochemistry},
  year={2005},
  volume={94 1},
  pages={169-80}
}
Although it is well established that RhoA signaling pathways play key roles in regulating neuronal morphology, their involvement in other aspects of neuronal function has received little attention. Recent studies have elucidated a novel intracellular signaling pathway used by RhoA to elicit activation of serum response factor (SRF)-mediated transcription. In this pathway, activation of RhoA triggers nuclear translocation of the SRF co-activator, megakaryocytic acute leukemia (MAL). In assessing… CONTINUE READING

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