Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cells.

@article{Wu2010NuclearTO,
  title={Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cells.},
  author={Wenqing Wu and Greg L. Beilhartz and Yvette Roy and Cynthia Lee Richard and Maureen Elizabeth Curtin and Lauren Hadley Brown and Danielle Cadieux and Marc G. Coppolino and Mary C. Farach-Carson and Ilka M. Nemere and Kelly Anne Meckling},
  journal={Experimental cell research},
  year={2010},
  volume={316 7},
  pages={
          1101-8
        }
}
1,25 Dihydroxyvitamin D(3) (1,25D(3)) primes NB4 promyelocytic leukemia cells to differentiate along the monocyte/macrophage lineage through a non-genomic mechanism. Here we show that NB4 cells express high levels of the recently identified membrane receptor for 1,25D(3), which is a distinct gene product from the classical nuclear vitamin D receptor. This 57 kDa protein, named 1,25D(3)-MARRS (Membrane Activated Rapid Response to Steroids)/ERp57/PIA3 appears to associate in a complex with the… CONTINUE READING
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