Nuclear translocation of cytosolic phospholipase A2 is induced by ATP depletion.

@article{Sheridan2001NuclearTO,
  title={Nuclear translocation of cytosolic phospholipase A2 is induced by ATP depletion.},
  author={Alice M Sheridan and Adam Sapirstein and Nicole Lemieux and Brooke D. Martin and Dae Kyong Kim and Joseph V. Bonventre},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={29899-905}
}
Phospholipase A(2) (PLA(2)) enzymes may play a role in cellular injury due to ATP depletion. Renal Madin-Darby canine kidney cells were subjected to ATP depletion to assess the effects of cellular energy metabolism on cytosolic PLA(2) (cPLA(2)) regulation. ATP depletion results in a decrease in soluble cPLA(2) activity and an increase in membrane-associated activity, which is reversed upon restoration of ATP levels by addition of dextrose. In ATP-depleted cells cPLA(2) mass shifts from cytosol… CONTINUE READING