Nuclear translocation of beta-catenin in colorectal cancer

  title={Nuclear translocation of beta-catenin in colorectal cancer},
  author={Michio Kobayashi and Taku Honma and Yasunobu Matsuda and Yasushi Suzuki and Rintaro Narisawa and Yoichi Ajioka and Hitoshi Asakura},
  journal={British Journal of Cancer},
  pages={1689 - 1693}
Post-translational stabilization of beta-catenin through mutation of the adenomatous polyposis coli (APC) gene has been proposed as an early step in colorectal carcinogenesis. Beta-catenin may translocate from the cytoplasm to the nucleus, where it might serve as a transcriptional factor to stimulate tumour formation. We investigated intracellular localization of beta-catenin in sporadic colorectal adenomas and cancers as well as familial adenomatous polyposis (FAP). Nuclear over-expression of… CONTINUE READING