Nuclear translocation of apoptosis inducing factor is associated with cisplatin induced apoptosis in LNCaP prostate cancer cells.

@article{Zhang2007NuclearTO,
  title={Nuclear translocation of apoptosis inducing factor is associated with cisplatin induced apoptosis in LNCaP prostate cancer cells.},
  author={Wenguang Zhang and Chuanyou Zhang and Narassa Narayani and Cheng Du and K. Chandra Sekhar Balaji},
  journal={Cancer letters},
  year={2007},
  volume={255 1},
  pages={
          127-34
        }
}
Prostate cancer (PC) is considered resistant to cisplatin chemotherapy. In order to identify novel causes of resistance to cisplatin, we explored the role of Apoptosis Inducing Factor (AIF) that mediates caspase independent apoptosis in cisplatin induced cell death in PC. Similar to treatment with pancaspase inhibitor Z-VAD-fmk, cisplatin induced apoptosis in LNCaP cells was inhibited by AIF inhibitor N-acetyl-L-cysteine (NAC), treatment of LNCaP cells with NAC prevented AIF translocation to… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.

  • Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND