Nuclear translocation of a maternal CCAAT factor at the start of gastrulation activates Xenopus GATA-2 transcription.

@article{Brewer1995NuclearTO,
  title={Nuclear translocation of a maternal CCAAT factor at the start of gastrulation activates Xenopus GATA-2 transcription.},
  author={Alison C. Brewer and Matthew J. Guille and David Fear and Greg A. Partington and Roger Patient},
  journal={The EMBO journal},
  year={1995},
  volume={14 4},
  pages={757-66}
}
The transcription factor GATA-2 is present in blood cell precursors and plays a pivotal role in the control of erythroid differentiation. In Xenopus embryos, low levels of GATA-2 mRNA are maternally derived, while the onset of zygotic GATA-2 expression coincides with commitment to haematopoietic lineages. However, its initial transcriptional activation is not restricted to the presumptive blood islands, but occurs throughout ventral and lateral regions, in all three germ layers. In order to… CONTINUE READING

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