Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.

@article{Sol2005NuclearTO,
  title={Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.},
  author={Susana Sol{\'a} and Joana D Amaral and Rui E Castro and Rita Cruz Coelho de Mira Ramalho and Pedro M. Borralho and Betsy T. Kren and Hirotoshi Tanaka and Cifford J Steer and Cec{\'i}lia M. P. Rodrigues},
  journal={Hepatology},
  year={2005},
  volume={42 4},
  pages={925-34}
}
Ursodeoxycholic acid (UDCA) inhibits classical mitochondrial pathways of apoptosis by either directly stabilizing mitochondrial membranes or modulating specific upstream targets. Furthermore, UDCA regulates apoptosis-related genes from transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis by a nuclear steroid receptor (NSR)-dependent mechanism. In this study, we further investigated the potential role of the glucocorticoid receptor (GR) in the anti-apoptotic function of UDCA… CONTINUE READING
24 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…