Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease.

@article{Hunot1997NuclearTO,
  title={Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease.},
  author={St{\'e}phane Hunot and Bernard Brugg and Damien Ricard and Patrick P Michel and Marie P Muriel and Merle Ruberg and Baptiste Faucheux and Yves Agid and Etienne C. Hirsch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 14},
  pages={7531-6}
}
Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration of dopaminergic neurons in Parkinson disease (PD) that have recently been shown to die by apoptosis, but the relationship between oxidative stress and apoptosis has not yet been elucidated. Activation of the transcription factor NF-kappaB is associated with oxidative stress-induced apoptosis in several nonneuronal in vitro models. To investigate whether it may play a role in PD, we looked for the… CONTINUE READING
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